Anti-virulence strategies to combat bacteria-mediated disease

Strategies to Combat Antibiotic Resistance

Strategies to Combat Software Piracy

It is impossible to combat software piracy as long as the machines on which the programs execute are indistinguishable; then, any program that can execute on one machine may be copied for execution on another machine. Recently, hardware manufacturers have begun assigning unique identifiers to CPU chips, which make it possible to address the piracy issue in a new light. In this paper, we suggest...

Oligonucleotide-based strategies to combat polyglutamine diseases

Considerable advances have been recently made in understanding the molecular aspects of pathogenesis and in developing therapeutic approaches for polyglutamine (polyQ) diseases. Studies on pathogenic mechanisms have extended our knowledge of mutant protein toxicity, confirmed the toxicity of mutant transcript and identified other toxic RNA and protein entities. One very promising therapeutic st...

Microbes offer engineering strategies to combat cancer

immune cells exist with interactive networks that dictate good health and disease, including cancer, both within and beyond the gut1–3. This emerging paradigm linking gut bac teria with extraintestinal cancer builds upon earlier work that tumour microenvironments interact with systemic immune and metabolic networks4, and, more specifically, with microbial– immune networks2,5,6. In this way, gut...

Novel Strategies to Combat Antimicrobial Resistance

Infectious diseases form the major health-care burden for the developing world and antimicrobials prove to be the magical drugs to combat this. The discovery of antimicrobial agents was boon for the global health-care system and the wonderful cure by antimicrobials shifted the disease trends from infectious to life-style diseases in the developed world. Sudden appearance of the antimicrobial re...